Utah Ketamine Authority

Ketamine and Depression

Ketamine and Treatment of Depression


Depression is an illness that negatively impacts how you think, feel, and act. Depression can cause changes in appetite, loss of interest in previously enjoyable activities, depressive feelings, trouble sleeping or sleeping too much, feelings of worthlessness, difficulty concentrating, and thoughts of suicide or death.


Depression, even when severe, is very treatable. Using interventions from Cognitive Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT) and Positive Psychology; clients will gain insight into how their reactions and behaviors influence their depressive thought patterns. Our counselors are ready to support you on your journey to change these thought patterns and embrace a better future.


Integrated Ketamine Assisted Psychotherapy (IKAP) is also a treatment option for client’s struggling with depression. IKAP is the combination of psychotherapy and an IV ketamine infusion. This process invites neuroplasticity (the ability to change and grow) within the brain’s neural connections. This allows clients the ability to process depressive thoughts, embrace change, and focus on hope for the future.


Resources and Relevant Studies

Esketamine: new hope for the treatment of treatment-resistant depression? A narrative review

The overall findings demonstrated that treatment with intranasal esketamine in combination with a new oral antidepressant was more effective than placebo plus an oral antidepressant, and associated with a rapid reduction of depressive symptoms and delayed time to relapse from symptoms of depression.76,78Consistent with the short-term esketamine studies, the long-term safety study showed that the esketamine doses studied were generally well tolerated, with no new safety concerns with dosing up to 52 weeks.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383653/

Ketamine treatment for depression: a review

Despite the preliminary nature of the evidence described above, a small number of studies have examined the promising effects of ketamine combined with psychotherapy for treating disorders other than depression, including alcohol, heroin, cocaine, and cannabis abuse [6972]. Ketamine was found to have benefits in treating substance addiction and dependence, increasing abstinence rates, reducing relapse rates, and decreasing cravings. Taken together, the positive findings from these preliminary studies suggest that the methodology involved in ketamine-assisted psychotherapy is presently evolving; additional studies are needed to optimize its use.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010394/